Silver Nanoparticle-Coated Polyhydroxyalkanoate Based Electrospun Fibers for Wound Dressing Applications

Wound dressings are high performance and value products which can improve the regeneration of damaged skin. In these products, bioresorption biocompatibility play a key role. The aim this study is to provide progress in area via nanofabrication antimicrobial natural materials. Polyhydroxyalkanoates (PHAs) bio-based family polymers that possess skin regenerative properties. study, blend poly(3-hydroxybutyrate) (P(3HB)) poly(3-hydroxyoctanoate-co-3-hydroxy decanoate) (P(3HO-co-3HD)) was electrospun into P(3HB))/P(3HO-co-3HD) nanofibers obtain materials with surface good handling performance. were then modified silver nanoparticles (AgNPs) dip-coating method. silver-containing nanofiber meshes showed cytocompatibility interesting immunomodulatory properties vitro, together capability stimulating human beta defensin 2 cytokeratin expression keratinocytes (HaCaT cells), makes them promising for wound dressing applications.